"Lost in Nightmares" came out first and since its release, Cary and I have played through it twice. Three times? I can't remember now. Suffice it to say, we've played through it several times and each time was just as enjoyable as the first. "Lost in Nightmares" is a great combination of old and new Resident Evil. Walking through doorways was similar to the older games. There were long, dark hallways where you would hear dogs, but then bats would burst through the window. (Which, of course, didn't scare Cary at all. Ha.) But this DLC was full of those moments where you were just waiting for something else to scare you... which felt like something that was missing from the original RE5 and was lots of fun.
You can watch a couple guys play co-op through "Lost in Nightmares" in this video to get a sense of just exactly how fun this DLC can be:
Now, "Desperate Escape" is a completely different story. Cary and I finished this in just under an hour and, by the end, we were both exhausted. This DLC is a non-stop fuckfest of infinite missiles and the biggest, most annoying enemies in the original RE5. We thought we had played the DLC so horribly that, at the end, when we received an achievement for getting an S rank in the DLC, we were almost in physical shock. This DLC does NOT fuck around. It doesn't let you stop to catch your breath and I guess if that's your kind of thing... okay. But I wouldn't say I really enjoyed myself.
All of that being said, these DLCs were somewhere along the lines of 400 Microsoft points, which is a bargain and a half. At least for "Lost in Nightmares." I can't say I feel the same way about "Desperate Escape."